Here’s an attempt to list some of the key issues (first appearances and significant events) to look for in the comic world. I’m building this list gradually so if you have something that you would like to add please comment and I’ll try and update the list.

Strange Tales 110 – First Doctor Strange

New Mutants 87 – First Cable

New Mutants 98 – First Deadpool

NYX 3 – First X-23

Hulk 181 – First Wolverine

Edge of Spiderverse 2 – First Spidergwen

Marvel Spotlight 5 – First Ghostrider

Luke Cage Hero for Hire 1 – First appearance of Luke Cage

X-Men 94 – First ongoing series with new x-men team

Werewolf by Night 32 – First Moon Knight

House of Secrets 92 – First Swamp Thing

The Amazing Spider-Man #129 (1974) – First Punisher

Giant-Size X-Men #1 (1975) – New X-Men Team

Superman’s Pal Jimmy Olsen #134 – First Darkseid

Iron Man #55 – First Thanos

Marvel Premiere #15 (1974) – First Iron Fist

Amazing Adventures #11 (1972) – First App of Furry Beast

Tomb of Dracula #10 (1973) – First Blade

Batman #232 (1971) – First Appearance, Ra’s Al Ghul

Marvel Preview #7 (1976) – First Appearance, Rocket Raccoon

Amazing Spider-Man #101 (1971) – First Morbius the Vampire

Detective Comics #400 (1970) – First Man-Bat

Amazing Spider-Man #121 – Death of Gwen Stacey

X-Men #101 (1976) – First Appearance, Phoenix

Iron Fist #14 (1977) – First Appearance, Sabre-Tooth

All-Star Comics #58 (1976) – First Appearance, Power Girl

Amazing Spider-Man #122 (1973) – Death of Green Goblin

Savage Tales #1 (1971) – First Appearance, Man-Thing

Ms. Marvel #1 (1977) – First Appearance of Carol Danvers as Ms. Marvel

Marvel Preview #4 (1976) – First Appearance, Star Lord

Captain Britain #8 (1976) – First Appearance Betsy Braddock / Psylocke

Marvel Spotlight #32 (1977) – First Appearance, Spider-Woman

Strange Tales #180 (1975) – First Appearance, Gamora

Adventure into Fear #19 (1973) – First Appearance, Howard the Duck

Daredevil #168 (1981) – First Appearance, Elektra

X-Men #120 (1979) – First Appearance, Alpha Flight

Detective Comics #411 (1971) – First Appearance, Talia al Ghul

New Teen Titans #2 (1980) – First Appearance, Deathstroke the Terminator

Batman Adventures #12 (1993) – 1st Appearance of Harley Quinn

Walking Dead #27 (2006) – 1st Appearance of the Governor

Batman Vengeance of Bane Special (1993) – 1st Appearance of Bane

Walking Dead #19 (2005) – 1st Appearance of Michonne

Walking Dead #100 (2012) – 1st Appearance of Negan

Marvel Super-Heroes #8 (1992,”Winter Special”) – 1st Appearance, Squirrel Girl

Starman 9 – First App of Blockbuster (The real one)

Aquaman 19 New 52 – King Nefareus (Villain in Aquaman Movie)

X-Men 49 – 1st Polaris